Diabetes Pathophysiology

Type2 diabetes mellitus is characterized by both combinations of inadequate insulin secretion by pancreatic beta cells and peripheral insulin resistance. Insulin resistance, which has been associated to proinflammatory cytokines in plasma and elevated levels of free fatty acids, it leads to decreased glucose transport into muscle cells, elevated hepatic glucose production, and increased breakdown of fat. The major role for excess glucagon cannot be underestimated; indeed, type 2 diabetes (T2D)  is an Islet Paracrinopathy in which the reciprocal relationship between the insulin-secreting beta cell and the glucagon-secreting alpha cell is lost, leading to hyperglucagonemia and hence the consequent hyperglycaemia. For type 2 diabetes mellitus (T2DM) to occur, both insulin resistance and inadequate insulin secretion must exist. For example, generally all overweight or obese individuals have insulin resistance, but diabetes develops only in those who cannot raise insulin secretion sufficiently to compensate for their insulin resistance. Their insulin concentrations may be high, yet inappropriately low for the level of glycaemia.

  • Acute pancreatitis symptoms
  • Identification of β-cell dysfunction and insulin resistance
  • Differentiation of diabetes by pathophysiology, natural history
  • Clinical features of diabetes mellitus

Related Conference of Diabetes Pathophysiology

February 27-28, 2019

Asia Pacific Diabetes and Endocrinology Congress

Tokyo, Japan

April 17-18, 2019

21st Asia Pacific Diabetes Conference

Osaka,Japan
May 17-18, 2019

2nd Global Experts Meeting on Diabetes, Hypertension & Metabolic Syndrome

Holiday Inn Singapore Atrium | Singapore
May 30-31, 2019

2nd Global Meeting on Diabetes and Endocrinology

Istanbul, Turkey
June 27-28, 2019 |

18th Global Conference on Diabetes & Nursing Care

Amsterdam, Netherlands
July 17-18, 2019

28th European Diabetes Congress

| Edinburgh, Scotland
July 24-25, 2019

29th World Diabetes & Heart Congress

Melbourne, Australia
July 29-30, 2019

12th International Conference on Diabetes & Metabolism

Chicago | Illinois| USA
September 19-20, 2019

15th World Congress on Endocrinology & Diabetes

| Prague, Czech Republic
Oct 03-04, 2019

Euro Diabetes Congress & Expo

| Paris, France
November 25-26, 2019

27th International Diabetes and Healthcare Conference

Istanbul, Turkey

Diabetes Pathophysiology Conference Speakers

Recommended Sessions

Related Journals

Are you interested in