Insulin and Beta Cell Targeting

Type2 diabetes mellitus is widely considered a chronic disease without a cure. As beta-cell function progressively declines most of the time, then blood glucose rises. However, recent studies have demonstrated remission of type2 diabetes following bariatric surgery, intensive insulin therapy or very low-calorie diet, raising the possibility that the declining beta-cell function in type2 diabetes may be arrested or even reversed. Future treatment strategies should be revised to target to early beta-cell preservation and those disease remissions.

  • Targeting β-cell mass in type 2 diabetes
  • B-cell science
  • The incretin effect and its mediators
  • Implications for treatment
  • Effects of the incretins on β-cell mass
  • Targeting the pancreatic β-cell to treat diabetes

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February 27-28, 2019

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