Insulin and Beta Cell Targeting

Type2 diabetes mellitus is widely considered as chronic disease without cure. When beta-cell function progressively declines most of the time, then only blood glucose level rises. However, recent studies have demonstrated remission of Type2 diabetes following bariatric surgery, intensive insulin therapy or very low calorie diet, raising the possibility that the declining beta-cell function in Type2 diabetes may be arrested or even reversed. Future treatment ways ought to be revised to focus on to early beta-cell preservation and people sickness remissions.

 

    • Targeting β-cell mass in type 2 diabetes
    • B-cell science
    • The incretin effect and its mediators
    • Implications for treatment
    • Effects of the incretins on β-cell mass
    • Targeting the pancreatic β-cell to treat diabetes

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