Islet Transplantation/Immunology of Type 1 Diabetes

Islet transplantation is an attractive method for the treatment of Type 1 diabetes, because of its minimal invasion to patients and potential high efficacy. The treatment may effectively control blood glucose levels for brittle Type 1 diabetes, resulting in an improvement in HbA1c and marked increase in hypoglycemic episodes. In addition, approximately 75% of transplanted Type 1 diabetic (T1D) patients have achieved insulin independence. However, there are still more important issues that to be addressed before this treatments and diagnosis are widely applicable, and including difficulty in maintaining insulin independence, multiple donor requirements, low islet isolation success rate, and side effects associated with the use of immunosuppressants. Here donor shortage is another dilemma. To addressing the issue of donor shortage, bioartificial islet transplantation and living donor islet transplantation using pig islets are being evaluated. Bioartificial islet transplantation could be the best solution of the donor shortage

  • Immune System in Health and Disease
  • Post transplantation monitoring
  • Islet transplantation for type 1 diabetes
  • Blood glucose management, and assessment of islet function
  • Challenges facing islet transplantation

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