Islet Transplantation/Immunology of Type 1 Diabetes

Islet transplantation is a beautiful technique for the treatment of kind one polygenic disorder, because of its minimal invasion to patients and potential high efficacy. The treatment may effectively control blood glucose levels for Type 1 diabetes that results in an improvement in HbA1c and may also result in the increase in hypoglycaemic conditions. Approximately 75% of transplanted Type 1 diabetic (T1D) patients have overcome this disorder. However, there are still more important issues that need to be addressed before this treatments and diagnosis are widely applicable, and including difficulty in maintaining insulin independence, multiple donor requirements, low islet isolation success rate, and side effects associated with the use of immunosuppressant. Here donor shortage is another dilemma. To addressing the issue of donor shortage, bioartificial islet transplantation and living donor islet transplantation using pig islets are being evaluated. Bioartificial islet transplantation may be the most effective resolution of the donor shortage.

  • Immune System in Health and Disease
  • Post transplantation monitoring
  • Islet transplantation for type 1 diabetes
  • Blood glucose management, and assessment of islet function
  • Challenges facing islet transplantation

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