Lipid Metabolism and Diabetes

Patients with diabetes regularly present with abnormal lipid profiles because insulin regulates many of the steps of lipid metabolism. Patients who with type 1 diabetes that exhibit adequate glycaemic control do not have quantitative lipoprotein abnormalities, but those exhibit qualitative abnormalities, primarily an increase in smaller, more atherogenic very low‐density lipoprotein (VLDL) particles. Moreover, in the Complications Trials (DCCT) study of diabetes, and Diabetes Control the both group of patients with type1 diabetes that were characterised by consistent weight gain, exhibited more lipid profiles in type 2 diabetes (T2D). Dyslipidaemia in type2 diabetes is characterised by many strictly linked abnormalities: a significant decrease in high‐density lipoprotein (HDL) cholesterol, elevated fasting and postprandial triglycerides (TG), and an increase in smaller low‐density lipoprotein (LDL) and HDL particles.

  • Hyperglycemia and insulin resistance
  • Dyslipidemia
  • Diabetes Control and Complications

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