Lipid Metabolism and Diabetes

Patients with polygenic disorder often show abnormal lipid profiles as a result of hormone regulates several steps of lipid metabolism. Patients those with Type1 diabetes exhibit adequate glycaemic control but do not have quantitative lipoprotein abnormalities, but those exhibit qualitative abnormalities, primarily an increase in smaller, more atherogenic very low‐density lipoprotein (VLDL) particles. Moreover, in the study of diabetes, and Diabetes Control & Complications Trial(DCCT), both group of patients with type1 diabetes were characterised by consistent weight gain, exhibited more lipid profiles in Type2 diabetes (T2D). Dyslipidaemia in Type2 diabetes is characterised by many strictly linked abnormalities: a significant decrease in high‐density lipoprotein (HDL) cholesterol, elevated fasting and postprandial triglycerides (TG), and an increase in smaller low‐density lipoprotein (LDL) and high density lipoprotein (HDL) particles.

  • Diabetes Control and Complications
  • Hyperglycemia and insulin resistance
  • Dyslipidemia

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