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International Conference on Diabetes and Cholesterol Metabolism, will be organized around the theme “Focus on Current Investigations, Treatment and Preventive Strategies for Diabetes & Metabolic Diseases”

Metabolic Diseases 2019 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Metabolic Diseases 2019

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Body mass index (BMI) has a most common relationship to diabetes and insulin resistance. In obesity patents having an amount of no esterified fatty acids, cytokines, glycerol, pro-inflammatory markers, hormones, and other substances that are involved in the development of insulin resistance, is increased. The pathogenesis in the development of diabetes is depending on the fact that the β-islet cells of the pancreas are impaired, causing a lack of control of blood glucose. The development of diabetes becomes additional inevitable if the failure of β-islet cells of the pancreas is accompanied by insulin resistance. Body mass and weight gain and are central to the formation and rising incidence of type 1 and type2 diabetes.

  • Track 1-1Obesity and type 1 diabetes
  • Track 1-2Obesity and type 2 diabetes
  • Track 1-3Obesity and insulin resistance
  • Track 1-4Diabetes mellitus and obesity

Diabetes is a metabolic condition in which the body decrease to produce enough insulin. Type1 and type2 diabetes both are caused by a combination of genetic and environmental risk factors. Because of that some other rare forms of diabetes that are directly inherited. That includes (MODY) maturity onset diabetes in the young, and diabetes due to mutations in mitochondrial DNA. In addition to the consequences of abnormal metabolism of glucose that are hyperlipidaemia, glycosylation of proteins, there are a number of long-term complications associated with the disease.  

Type1Diabetes is caused by the autoimmune destruction of the beta cells of the pancreas and represents approximately 10.5% of all cases with diabetes. Generally lifelong insulin therapy is the only treatment for this disorder. Without exogenous insulin injections, individuals with Type1Diabetes will not survive. Type2 Diabetes is the most frequent form of the disorder, accounting for approximately 95% of all affected individuals. A diagnosis of Type2 Diabetes mellitus is made if a fasting plasma glucose concentration is > 7.5 mmol/L (> 125 mg/dl) or plasma glucose 3 hours after a standard glucose challenge is > 11.5 mmol/L (> 280 mg/dl) (WHO, 1999) Type2 Diabetes is caused by relative impaired insulin secretion and peripheral insulin resistance.

  • Track 2-1Etiology of the diabetes epidemic
  • Track 2-2Heritability of diabetes
  • Track 2-3Genetic studies on Type1 and Type 2 Diabetes
  • Track 2-4The value of monogenic subtypes of diabetes
  • Track 2-5Factors contributing to the complexity of analysis
  • Track 2-6Emerging patterns and implications for study design
  • Track 2-7DNA diagnostics and pharmacogenetics in clinical trials

Hyperglycaemia and hypoglycaemia these both conditions could be part of silent diabetes symptoms of they both involve difficulty regulating blood sugar, or glucose. Hypoglycaemia occurs when the level of insulin in the blood is more than glucose, lowering glucose to levels below 72 mg/dL (3.8mmol/L). The brain is at risk when glucose dips below 72 mg/dL (3. 8 mmol/L). Symptoms of hypoglycaemia includes Shaking, sweating, or clammy skin, Sudden nervousness, confusion, headache, or irritability, Rapid heart rate, Dizziness, weakness, or fatigue, Hunger and nausea.

High blood glucose levels lead to Complication of Hyperglycaemia. It is a life-threatening condition. It requires immediate medical attention. Physical signs and symptoms of Hyperglycaemia Extreme thirst, frequent urination, General weakness, abdominal pain, High fever (greater than 101 degrees F)Sleepiness or confusion, Hallucinations.

  • Track 3-1Signs of hyperglycemia
  • Track 3-2Signs of hypoglycaemia
  • Track 3-3Hypoglycaemia in an individual with diabetes
  • Track 3-4Low blood glucose
  • Track 3-5Severe complications from hyperglycaemia
  • Track 3-6Ways to manage hypoglycaemia and hyperglycemia

Endocrine disorders involve the abnormality of over- or under-production of certain hormones, among the endocrine disorders, thyroid problems are the most common. Endocrine disorders include hypothyroidism, diseases of the parathyroid gland, congenital adrenal hyperplasia, diabetes mellitus, ovarian dysfunction (including polycystic ovary syndrome) and diseases of the adrenal glands (Cushing’s syndrome and Addison’s disease), among others. Metabolic disorders affect the body’s ability to process certain vitamins and nutrients. Some examples of metabolic disorders include cystic fibrosis, hyperlipidaemia, phenylketonuria (PKU), gout, and rickets.

Polycystic ovary syndrome is one of the most common endocrine disorders among women’s reproductive system. Hypothyroidism and hyperthyroidism are also common endocrine disorders.

  • Track 4-1Thyroid growths
  • Track 4-2Thyroid under activity/over activity
  • Track 4-3Endocrine reproductive disorders
  • Track 4-4Hyperlipidaemia
  • Track 4-5Osteoporosis
  • Track 4-6Thyroid and Parathyroid diseases
  • Track 4-7Metabolic bone diseases
  • Track 4-8Neuroendocrine diseases
  • Track 4-9Clinical approach to endocrine and metabolic diseases

Type2 diabetes (T2B) is a chronic condition that effects on the body metabolizes sugar, also known as glucose. Between 2014 and 2015, about 25 present of new diabetes diagnoses in children were type2 diabetes. Being overweight is closely related to the development of type 2 diabetes mellitus. Genetics also play a major role for developing the diabetes in children.

Symptoms of type 2 diabetes (T2D) aren’t always easy to spot. In most of the cases, the disease is develops gradually, making the symptoms hard to detect. Those symptoms are excessive fatigue, frequent urination, increased hunger, Excessive thirst, Slow-healing sores, darkened skin under the back neck. Sometimes it takes many months to get a type 2 diabetes diagnosis for a child.

  • Track 5-1Diabetes in children
  • Track 5-2Insulin adjustment in children
  • Track 5-3Managing and monitoring of diabetes in children
  • Track 5-4Childhood obesity and type 2 diabetes mellitus
  • Track 5-5Glucose metabolism and regulation
  • Track 5-6Alternative drug treatments in childhood type 2 diabetes
  • Track 5-7Lifestyle modifications
  • Track 5-8Management of combinations and complication childhood diabetes

Endocrine disorders can be extremely complex and they can profoundly affect human’s health. Endocrine system is made up of thyroid, parathyroid, ovaries, testes, pancreas, adrenal, pituitary, and hypothalmus glands. These endocrine glands are produce chemicals called hormones. These hormones are released into the blood stream and their action by stimulating other organs in the body. These hormones from the glands regulate growth, blood pressure, metabolism, reproduction as well as many other necessary functions. Conditions which may influence by Endocrine system are Adrenal Disorders, Diabetes Mellitus, Hyperparathyroidism, Obesity, Osteoporosis, Rheumatic Disorders and Thyroid Disorders.

  • Track 6-1Endocrine and metabolic disorders
  • Track 6-2Anaplastic thyroid cancer
  • Track 6-3Growth hormone deficiency
  • Track 6-4Congenital adrenal hyperplasia

The relative abundance of lack of rigorous exercise and food common in modern life pose serious challenges in the incidence and treatment of these diseases and their complications. Although blood glucose controlling agents such as oral hypoglycaemic agents and insulin are available, most currently available drugs have been shown to exhibit minimal to moderate efficacy and many of them have serious side effects. Obesity is an important risk factor for type 2 diabetes mellitus. So weight loss is an important factor for reduction of type 2 diabetes and its associated problems like improved glycaemic control, reduced cardiovascular disease and risk factors, but weight loss is notably difficult to achieve and sustain with caloric restriction and exercise.

  • Track 7-1Diet, physical activity, and behavioural therapy
  • Track 7-2Herbal drugs used for the treatment of diabetes
  • Track 7-3Diabetes treatment with stem cells
  • Track 7-4Pathophysiology and treatment of type 2 diabetes
  • Track 7-5Potential risk factors of type 2 diabetes

Diabetic eye Complications comprises a group of eye conditions that effect on people with diabetes. These conditions are called diabetic retinopathy, diabetic macular edema (DME), cataract, and glaucoma. Diabetic retinopathy may cause mild vision problems. Eventually, it may cause blindness also. This condition can develops in anyone who has type 1diabetes or type 2 diabetes. People who may have diabetes and who having less controlled blood sugar, in that people this condition were develop.

  • Track 8-1Retinal abnormality
  • Track 8-2Diabetic retinopathy
  • Track 8-3Diabetic Macular Edema (DME)
  • Track 8-4Non-proliferative retinopathy

A metabolic disease occurs when the metabolism processor fails and causes the body to have either much more or very little of the essential substances needed to stay healthy. Diabetes is also a metabolic disease. Metabolic disorder is any of the diseases that disrupt normal metabolism, the mechanism of converting food to energy on a cellular level. Lots of enzymes participating in numerous interdependent metabolic pathways carry out this process. Metabolic disorders may effects on the ability of the cell to perform critical biochemical metabolism that involve the processing or of proteins (amino acids), carbohydrates, or lipids (fatty acids). Metabolic diseases are typically hereditary, yet most persons affected by them may appear healthy for months, or even years. The onset of symptoms generally occurs when the body’s metabolism comes under stress.

  • Track 9-1Potential mechanism of SGLT2I induced euglycaemic diabetic ketoacidosis
  • Track 9-2Anorexia nervosa
  • Track 9-3New insight into diabetes and metabolic disease
  • Track 9-4Insulin tropic agents from medicinal plants

Diabetic coma is a dangerous diabetes complication that causes unconsciousness. When blood sugar levels are too high or too low then that serious condition can lead to a diabetic coma. Before developing a diabetic coma, usually some experiences of signs that will shows like high blood sugar or low blood sugar. High blood sugar (hyperglycaemia) symptoms are increased thirst, frequent urination, Fatigue, Nausea and vomiting, Shortness of breath, Stomach pain, a very dry mouth and a rapid heartbeat. Signs and symptoms of a low blood sugar level may include Shakiness or nervousness, Anxiety, Fatigue, Weakness, Sweating, Hunger, Nausea, Dizziness or lightheadedness, Difficulty speaking, Confusion.

Diabetes is an endocrine system disease, endocrinology nurses may work with people who have diabetes, and go by the title diabetes nurse. Diabetes mellitus has a general problem of endocrine system. The diabetes nurses are educators and disease management specialists able to provide patients with the information and treatment they need to effectively manage their diabetes. The main additional responsibilities of diabetes nurse are providing nutritional therapy, adjusting the type and dosage of medication, and providing behavioral and psychiatric care.

  • Track 10-1Diabetic hypoglycaemic coma
  • Track 10-2Diabetic hypoglycaemic coma
  • Track 10-3Diabetic ketoacidosis coma
  • Track 10-4Professionals working in the field of diabetes nursing
  • Track 10-5Diabetes mellitus medications & nursing management
  • Track 10-6Roles and responsibilities of nurses

A new tool that is “control-variability grid analysis (CVGA)” for measuring the quality of closed-loop glucose regulation on a group of subjects is introduced. It is one of  method for visualization of the extreme glucose excursions caused by a control algorithm in a group of subjects, with each subject presented by one data point for any given observation period.

Self-monitoring of blood glucose should be part of a regular management plan for patients with diabetes. Self-monitoring of blood glucose provides complete information regarding an individual's dynamic blood glucose profile. Self-monitoring of blood glucose is an essential tool for people who with diabetes who are taking insulin or those who experience fluctuations in their blood glucose levels, especially hypoglycaemia.

  • Track 11-1Mobile technology for self-monitoring
  • Track 11-2Flash glucose-sensing technology
  • Track 11-3Principles and practice for self-monitoring
  • Track 11-4Novel smartphone-coupled blood glucose monitoring system
  • Track 11-5Home telehealth
  • Track 11-6Advancing blood glucose meter technology

The term pre-diabetes has first used to denote abnormalities of pregnancy (e.g., hydramnios, high–birth weight babies) or a strong family history of type2 diabetes. WHO (World Health Organization) discarded the term largely because many subjects with borderline glucose levels do not convert in to diabetes and because many would be afraid unnecessarily. According to Current researches reintroduced pre-diabetes to explain impaired glucose tolerance (IGT) and impaired Current researches (IFG) but no other risk factors for diabetes. So physician they suggested “intermediate hyperglycaemia” to Signify IGT and IFG for the Pre-diabetes patinas. 

  • Track 12-1Prediabetes and Metabolic Syndrome: Current trend
  • Track 12-2Prediabetic neuropathy
  • Track 12-3Awareness of prediabetes
  • Track 12-4Protective effects of fish oil on pre-diabetes
  • Track 12-5Pre-Diabetes as Intermediate Hyperglycemia
  • Track 12-6Gender-related affecting factors of prediabetes
  • Track 12-7Pathogenesis of intermediate hyperglycemia

Type2 diabetes mellitus is widely considered a chronic disease without cure. As beta-cell function progressively declines most of the time, then blood glucose rises. However, recent studies have demonstrated remission of type2 diabetes following bariatric surgery, intensive insulin therapy or very low calorie diet, raising the possibility that the declining beta-cell function in type2 diabetes may be arrested or even reversed. Future treatment strategies should be revised to target to early beta-cell preservation and those disease remissions. 

  • Track 13-1Targeting β-cell mass in type 2 diabetes
  • Track 13-2B-cell science
  • Track 13-3The incretin effect and its mediators
  • Track 13-4Implications for treatment
  • Track 13-5Effects of the incretins on β-cell mass
  • Track 13-6Targeting the pancreatic β-cell to treat diabetes

Islet transplantation is an attractive method for the treatment of Type 1 diabetes, because of its minimal invasion to patients and potential high efficacy. The treatment may effectively control blood glucose levels for brittle Type 1 diabetes, resulting in an improvement in HbA1c and marked increase in hypoglycaemic episodes. In addition, approximately 75% of transplanted Type 1 diabetic (T1D) patients have achieved insulin independence. However, there are still more important issues that to be addressed before the this treatments and diagnosis are widely applicable, and including difficulty in maintaining insulin independence, multiple donor requirements, low islet isolation success rate, and side effects associated with the use of immunosuppressant’s. Here donor shortage is another dilemma. To addressing the issue of donor shortage, bioartificial islet transplantation and living donor islet transplantation using pig islets are being evaluated. Bioartificial islet transplantation could be the best solution of the donor shortage. 

  • Track 14-1Immune System in Health and Disease
  • Track 14-2Post transplantation monitoring
  • Track 14-3Islet transplantation for type 1 diabetes
  • Track 14-4Blood glucose management, and assessment of islet function
  • Track 14-5Challenges facing islet transplantation

Type2 diabetes mellitus is characterized by a both combinations of inadequate insulin secretion by pancreatic beta cells and peripheral insulin resistance. Insulin resistance, which has been associate to proinflammatory cytokines in plasma  and elevated levels of free fatty acids, it  leads to decreased glucose transport into muscle cells, elevated hepatic glucose production, and increased breakdown of fat. The major role for excess glucagon cannot be underestimated; indeed, type 2 diabetes (T2D)  is an islet paracrinopathy in which the reciprocal relationship between the insulin-secreting beta cell and the glucagon-secreting alpha cell is lost, leading to hyperglucagonemia and hence the consequent hyperglycaemia. For type 2 diabetes mellitus (T2DM) to occur, both insulin resistance and inadequate insulin secretion must exist. For example, generally all overweight or obese individuals have insulin resistance, but diabetes develops only in those who cannot raise insulin secretion sufficiently to compensate for their insulin resistance. Their insulin concentrations may be high, yet inappropriately low for the level of glycaemia.

  • Track 15-1Acute pancreatitis symptoms
  • Track 15-2Identification of β-cell dysfunction and insulin resistance
  • Track 15-3Differentiation of diabetes by pathophysiology, natural history
  • Track 15-4Clinical features of diabetes mellitus

Cholesterol helps to body building of insulate nerves, new cells and produce hormones. Generally, the liver makes all the cholesterol the body needs. But sometimes cholesterol travels around in your bloodstream in high-density lipoproteins (HDL) and low-density lipoproteins (LDL).

HDL is also called as “good cholesterol” because it picks up cholesterol and takes it back to the liver for disposal. LDL transmits cholesterol in to the parts of body that need it. It is sometimes referred as “bad cholesterol”. If blood stream having this bad cholesterol, it can cling to the walls of heart arteries, eventually clogging them. Too much cholesterol in taking is risk factor for cardiac diseases. Some dietary intake factors influence to the risk of CAD include trans-fats, saturated fats, and polyunsaturated fatty acids

  • Track 16-1Menopause and cardiovascular disease
  • Track 16-2Low HDL cholesterol
  • Track 16-3High LDL cholesterol
  • Track 16-4Serum cholesterol
  • Track 16-5Genetic risk factor for coronary artery disease

Cholesterol is a waxy material, fat-like substance that developed naturally in the human body. Many people think of cholesterol as being harmful, but the real truth is that it's essential for total body to function, like making of vitamin D, and hormones, and perform various other important functions. But cholesterol absorbs a relatively small amounts from certain foods, such as eggs, meat and full-fat dairy products. Human bodies having two types of cholesterols that are: dietary cholesterol and serum cholesterol. Dietary cholesterol is found in the food people eat, and serum cholesterol naturally exists in our blood, and can rise to an unhealthy level leading to heart disease and clogged arteries. Cholesterol that is carried throughout the blood by something called lipoproteins.

Cholesterol metabolism is most frequent endogenous cause of diabetic Mellitus states. In this mainly three main mechanisms seem to be involved in these alterations: 1) an increased glycation of cholesterol-rich lipoproteins, 2) an insulin-resistant state which is mainly present in overweight type 2 diabetic patients, and 3) changes in insulin secretion which depends on the clinical type of diabetes.

  • Track 17-1Cholesterol-Free Food
  • Track 17-2Portfolio Diet
  • Track 17-3Dietary Cholesterol and Heart Disease
  • Track 17-4Interaction between Glucose and Lipid Metabolism
  • Track 17-5Cholesterol and glucose metabolism

Patients with diabetes regularly present with abnormal lipid profiles because insulin regulates many of the steps of lipid metabolism. Patients who with type 1 diabetes that exhibit adequate glycaemic control do not have quantitative lipoprotein abnormalities, but those exhibit qualitative abnormalities, primarily an increase in smaller, more atherogenic very low‐density lipoprotein (VLDL) particles. Moreover, in the Complications Trials (DCCT) study of diabetes, and Diabetes Control the both group of patients with type1 diabetes that were characterised by consistent weight gain, exhibited more lipid profiles in type 2 diabetes (T2D). Dyslipidaemia in type2 diabetes is characterised by many strictly linked abnormalities: a significant decrease in high‐density lipoprotein (HDL) cholesterol, elevated fasting and postprandial triglycerides (TG), and an increase in smaller low‐density lipoprotein (LDL) and HDL particles.

  • Track 18-1Hyperglycemia and insulin resistance
  • Track 18-2Dyslipidemia
  • Track 18-3Diabetes Control and Complications

Having diabetes means in that person more likely to develop congenital heart disease and have a greater chance of a heart attack or a stroke also. People with diabetes are also more likely to have certain conditions, which increase the chances of having heart disease, such as high blood pressure or cholesterol. If person have diabetes, that person can protect their heart and health by managing blood glucose, also called blood sugar, as well as blood pressure and cholesterol. Over time, that sugar build-up damages human nerves, heart, blood vessels and kidneys. The long-time person heaving diabetes, then higher chances that person will develop heart disease.

Diabetic heart disease is treated with lifestyle changes, medical procedures and medicines. The goals of treating diabeti heart disease include:

  • Controlling diabetes and any other heart disease risk factors person have, unhealthy blood cholesterol levels and high blood pressure
  • Reducing or relieving heart disease symptoms, such as angina (discomfort or chest pain)
  • Preventing or delaying heart disease complications, such as a heart attack
  • Repairing heart and coronary artery damage
  • Track 19-1Risks associated with T2D and CVD
  • Track 19-2Diabetic cardiomyopathy
  • Track 19-3Diabetes, heart disease, and stroke
  • Track 19-4Abnormal cholesterol levels
  • Track 19-5Family history of heart disease

Diabetic kidney disease is defined as macro albuminuria (albumin to creatinine ratio [ACR] >35 mg/mmol [400 mg/g]), or micro albuminuria (ACR 3.5-35.0 mg/mmol [35-400 mg/g]) associated with retinopathy (type 1 Diabetes or type 2 diabetes) and/or >11 years' duration of type 1 diabetes mellitus (T1DM).The terms 'moderately increased albuminuria' and 'severely increased albuminuria' are now frequently used instead of micro albuminuria and macro albuminuria. In most patients with diabetes, chronic kidney disease can be attributable to diabetes mellitus if these criteria are met. Other causes of diabetic kidney diseases should be considered in the presence of any of the following circumstances: rapidly decreasing GFR, absence of diabetic retinopathy, presence of active urinary sediment, or signs or symptoms of other systemic disease. The characteristic clinical presentation is progressive albuminuria, hypertension, and decline in GFR in a long-standing (duration >11 years) diabetic patient. The diagnosis is most of the time conclusively made by kidney biopsy, though it is rarely necessary.

  • Track 20-1Non-diabetic kidney disease
  • Track 20-2Renal tract obstruction
  • Track 20-3Multiple myeloma
  • Track 20-4Use of drug therapies for glycemic control

Diabetic neuropathy (DN) is caused by high blood sugar levels sustained over a long period of time. Other factors can lead to nerve damage that are lifestyle factors, such as alcohol or smoking use, damage to the blood vessels, such as damage done by high cholesterol levels, and mechanical injury, such as injuries caused by carpal tunnel syndrome. Low levels of vitamin B-12 can also lead to Diabetic neuropathy.

There is no cure for diabetic neuropathy (DN), but treatment can slow the progression of the condition. Treatment can also help to manage symptoms, such as pain and indigestion. 

  • Track 21-1Diabetic Neuropathies
  • Track 21-2Peripheral Neuropathy and Diabetes
  • Track 21-3Proximal neuropathy
  • Track 21-4Focal neuropathy

Diabetes can cause problems during pregnancy for women and their growing babies. Less control of diabetes during pregnancy will increases the chances for birth defects and other problems for the pregnancy. It can also cause serious complications for the pregnant woman. Proper health care before and during pregnancy can help prevent other health problems and birth defects.

Diabetes can affects baby’s organs, such as the heart, kidneys, brain, and lungs, start forming during the first 8 weeks of pregnancy. Increased blood glucose levels can be harmful during those early stages and it can increase the chance that on baby will have birth defects, such as heart defects or defects of the brain or spine.

  • Track 22-1Fetal and neonatal consequences of maternal diabetes
  • Track 22-2Prenatal care for the pregnant diabetic patient
  • Track 22-3Fetal macrosomia
  • Track 22-4Contraception for women with diabetes
  • Track 22-5Intrapartum and postpartum management of diabetes

The relative abundance of lack of rigorous exercise and food common in modern life pose serious challenges in the incidence and treatment of these diseases and their complications. Although blood glucose controlling agents such as oral hypoglycaemic agents and insulin are available, most currently available drugs have been shown to exhibit minimal to moderate efficacy and many of them have serious side effects. Obesity is an important risk factor for type 2 diabetes. Weight loss in patients with type 2 diabetes is associated with improved glycaemic control and reduced cardiovascular disease risk factors, but weight loss is notably difficult to achieve and sustain with caloric restriction and exercise.

  • Track 23-1Diet, Physical Activity, and Behavioral Therapy
  • Track 23-2Obesity with antidiuretic drugs
  • Track 23-3Pharmacologic Interventions
  • Track 23-4Assessment of glycemic control

Lifestyle changes are recommended as treatment for adults at risk for Diabetic and metabolic syndrome, although adoption of new behavioral patterns is limited. This Metabolic Syndrome can lead to life threatening major risk factors such as cardiovascular disorders, diabetic, obesity and thyroid disease. Till now the management of metabolic syndrome is limited only up to the use of drugs that correct dyslipidemia, blood pressure and hyperglycemia. In this regards the Yoga and Natural therapies based line of management with the help of diet, yoga, meditation and with the use of natural herbs, can establish a mile stone in the management of metabolic syndrome. By using natural herbs and remedies ailments develop due to the presence of intoxicants which are removed. Then automatically people will cures from their diseases and makes bodies strong and glowing.

  • Track 24-1Yoga-based diabetes management
  • Track 24-2Occupational therapy
  • Track 24-3Natural remedies for metabolic syndrome
  • Track 24-4Herbal phosphodiesterase inhibitors
  • Track 24-5Alternative natural sweeteners for diabetes