Diabetic Pathophysiology
Type2 diabetes mellitus is characterized by a both combinations of inadequate insulin secretion by pancreatic beta cells and peripheral insulin resistance. Insulin resistance, which has been associate to proinflammatory cytokines in plasma and elevated levels of free fatty acids, it leads to decreased glucose transport into muscle cells, elevated hepatic glucose production, and increased breakdown of fat. The major role for excess glucagon cannot be underestimated; indeed, Type2 diabetes (T2D) is an islet paracrinopathy in which the reciprocal relationship between the insulin-secreting beta cell and the glucagon-secreting alpha cell is lost, which leads to hyperglucagonemia and hence the consequent hyperglycaemia. For type 2 diabetes mellitus (T2DM) to occur, both insulin resistance and inadequate insulin secretion must exist. Generally all overweight or obese individuals have insulin resistance, but diabetes develops only in those individuals who cannot raise insulin secretion to that level so that it can compensate for their insulin resistance. Their insulin concentrations may be high, which results in low level of glycaemia.
- Acute pancreatitis symptoms
- Identification of β-cell dysfunction and insulin resistance
- Differentiation of diabetes by pathophysiology, natural history
- Clinical features of diabetes mellitus
Related Conference of Diabetic Pathophysiology
September 29-30, 2025
24th International Conference on Diabetes, Nutrition, Obesity and Eating Disorders
Rome, Italy
November 06-07, 2025
34th International Conference on Clinical Diabetes, Diabetic Medication & Treatment
Berlin,
November 10-11, 2025
29th International Conference on Diabetes, Endocrinology and Healthcare
Paris, France
February 09-10, 2026
20th International Conference on Endocrinology, Diabetes and Metabolism
Singapore City, Singapore
February 12-13, 2026
5th Global Summit on Physiology and Metabolism of Thyroid
Singapore City, Singapore
April 27-28, 2026
37th International Congress on Prevention of Diabetes and Complications
Vancouver, Canada
April 27-28, 2026
32nd International Conference on Human Metabolic Health- Diabetes, Obesity & Endocrinology
Dubai, UAE
June 08-09, 2026
3rd International Congress on Endocrinology and Complications of Diabetes
Rome, Italy
September 23-24, 2026
24th Global Conference on Diabetes, Endocrinology and Primary Healthcare
Aix-en-Provence, France
Diabetic Pathophysiology Conference Speakers
Recommended Sessions
Related Journals
Are you interested in
- Adrenal and Pituitary Disorders - ENDOCRINOLOGY-2025 (Canada)
- Adrenal and Pituitary Disorders - Diabetes Conference 2026 (Netherlands)
- Advances in Diabetes Management - Endocrinology Conference 2025 (France)
- Advances in Endocrine Pharmacology - Global Diabetes 2026 (France)
- Advances in Endocrinology - ENDOCRINOLOGY-2025 (Canada)
- Advances in Endocrinology Metabolism - ENDOCRINE CONFERENCE 2025 (Spain)
- Advances in Hormone Replacement Therapies - Endocrinology Conference 2025 (France)
- Advances in Insulin and GLP-1 Therapies - Endocrinology Conference 2025 (France)
- Advances in Type 1 and Type 2 Diabetes - Diabetes-2026 (UK)
- AI in Diabetes Risk Prediction - Diabetes AsiaPacific 2025 (Germany)
- Andrology - ENDOCRINE CONFERENCE 2025 (Spain)
- Artificial Intelligence (AI) & Digital Health in Diabetes - Diabetes-2026 (UK)
- Artificial Intelligence in Diabetes Management - Diabetes Meeting 2026 (Canada)
- Artificial Intelligence in Endocrinology and Diabetes - Endocrinology Conference 2025 (France)
- Artificial Intelligence: The Future for Diabetes Care - Herbal Diabetes 2025 (France)
- Artificial Pancreas - Diabetic Nutrition 2025 (Italy)
- Artificial Pancreas and Closed-Loop Systems - ENDOCRINOLOGY-2025 (Canada)
- Autoimmunity and the Endocrine System - Global Diabetes 2026 (France)
- Beta Cell Regeneration - Diabetes AsiaPacific 2025 (Germany)
- Biomarkers and Diagnostic Tools - Euro Diabetes 2025 (Italy)
- Blood Glucose Dynamics and Monitoring - Herbal Diabetes 2025 (France)
- Bone Health - Euro Endocrinology 2026 (UK)
- Cardio-Endocrine Interplay - Global Diabetes 2026 (France)
- Cardio-endocrinology - ENDOCRINE CONFERENCE 2025 (Spain)
- Cardiovascular Disease Prevention - Euro Diabetes 2025 (Italy)
- Central Nervous Function in Relation to Obesity and Type 2 Diabetes - Diabetic Nutrition 2025 (Italy)
- Childhood Obesity - Euro Endocrinology 2026 (UK)
- Circadian Rhythms - Euro Endocrinology 2026 (UK)
- Circadian Rhythms and Insulin Sensitivity - Diabetes AsiaPacific 2025 (Germany)
- Clinical and Preclinical Pancreas Immunology and Islet Function - Diabetic Nutrition 2025 (Italy)
- Clinical Care and Education - Herbal Diabetes 2025 (France)
- Clinical Decision Support Systems/Advisors - Diabetic Nutrition 2025 (Italy)
- Clinical Trials and Drug Development in Diabetes - Diabetes-2026 (UK)
- Clinical Trials in Endocrinology and Diabetes - Endocrinology Conference 2025 (France)
- Closed-loop System & Algorithm - Diabetic Nutrition 2025 (Italy)
- Complications of Hormone Replacement Therapy (HRT) - ENDOCRINOLOGY-2025 (Canada)
- Continuous Glucose Monitoring (CGM) & Biosensors - Diabetes-2026 (UK)
- Continuous Glucose Monitoring (CGM) Technologies - Diabetes Meeting 2026 (Canada)
- Continuous Glucose Monitoring Innovations - Diabetes AsiaPacific 2025 (Germany)
- COVID-19 and Diabetes - Diabetic Nutrition 2025 (Italy)
- COVID-19 and Diabetes, Post-COVID Diabetes - Herbal Diabetes 2025 (France)
- CRISPR and Type 1 Diabetes - Diabetes AsiaPacific 2025 (Germany)
- Critical Endocrine Care in Acute Settings - Global Diabetes 2026 (France)
- Diabetes - Euro Endocrinology 2026 (UK)
- Diabetes and Cancer - ENDOCRINE CONFERENCE 2025 (Spain)
- Diabetes and Cancer Connections - Diabetes AsiaPacific 2025 (Germany)
- Diabetes and Cardiology - Herbal Diabetes 2025 (France)
- Diabetes and Cardiovascular Disease: A Dual Epidemic - Endocrinology Conference 2025 (France)
- Diabetes and Cardiovascular Diseases - Diabetes-2026 (UK)
- Diabetes and Cardiovascular Health - ENDOCRINOLOGY-2025 (Canada)
- Diabetes and Cardiovascular Health - Diabetes Conference 2026 (Netherlands)
- Diabetes and Cardiovascular Risk - Diabetes Meeting 2026 (Canada)
- Diabetes and Cognitive Decline - Diabetes AsiaPacific 2025 (Germany)
- Diabetes and Epigenetics - Diabetes AsiaPacific 2025 (Germany)
- Diabetes and Kidney Disease: From Pathogenesis to Management - Endocrinology Conference 2025 (France)
- Diabetes and Mental health - Euro Diabetes 2025 (Italy)
- Diabetes and Mental Health - ENDOCRINE CONFERENCE 2025 (Spain)
- Diabetes and Mental Health - Diabetes-2026 (UK)
- Diabetes and Mental Health - Diabetes Meeting 2026 (Canada)
- Diabetes and Metabolic Syndrome - Euro Diabetes 2025 (Italy)
- Diabetes and Metabolic Syndrome - Diabetes Conference 2026 (Netherlands)
- Diabetes and Pregnancy - Diabetes Meeting 2026 (Canada)
- Diabetes Complications - Diabetes Meeting 2026 (Canada)
- Diabetes Complications: Diagnosis and Management - Endocrinology Conference 2025 (France)
- Diabetes Education and Public Health - ENDOCRINOLOGY-2025 (Canada)
- Diabetes Education and Self-Management - Euro Diabetes 2025 (Italy)
- Diabetes Education, Self-Management & Patient Advocacy - Diabetes-2026 (UK)
- Diabetes Etiology - Herbal Diabetes 2025 (France)
- Diabetes Genetics, Biomarkers and Epidemiology - Diabetic Nutrition 2025 (Italy)
- Diabetes Healthcare Management - ENDOCRINE CONFERENCE 2025 (Spain)
- Diabetes Heredity and Genomics - ENDOCRINE CONFERENCE 2025 (Spain)
- Diabetes Immunotherapy - ENDOCRINE CONFERENCE 2025 (Spain)
- Diabetes in Adolescents - Diabetes Meeting 2026 (Canada)
- Diabetes in Aging Populations - Diabetes-2026 (UK)
- Diabetes in Special Population - Euro Diabetes 2025 (Italy)
- Diabetes Macrovascular Complications - Diabetic Nutrition 2025 (Italy)
- Diabetes Management - Diabetes Meeting 2026 (Canada)
- Diabetes Management Innovations - Euro Endocrinology 2026 (UK)
- Diabetes Mechanisms in Obesity and More - Diabetic Nutrition 2025 (Italy)
- Diabetes Mellitus - Herbal Diabetes 2025 (France)
- Diabetes Prevention - Euro Endocrinology 2026 (UK)
- Diabetes Prevention and Public Health - Euro Diabetes 2025 (Italy)
- Diabetes Prevention and Public Health - Diabetes Conference 2026 (Netherlands)
- Diabetes Research and Therapeutics - ENDOCRINOLOGY-2025 (Canada)
- Diabetes Research and Therapeutics - Diabetes Conference 2026 (Netherlands)
- Diabetes Symptoms and Complications - Herbal Diabetes 2025 (France)
- Diabetes Technology and Societal Impact - Diabetic Nutrition 2025 (Italy)
- Diabetes Technology: Continuous Glucose Monitoring and Insulin Delivery - Euro Diabetes 2025 (Italy)
- Diabetes Treatment - Diabetes Meeting 2026 (Canada)
- Diabetes Treatments - Euro Endocrinology 2026 (UK)
- Diabetes: Advanced Technologies and Treatments - Herbal Diabetes 2025 (France)
- Diabetic Clinical Care and Prevention - Diabetes Meeting 2026 (Canada)
- Diabetic complications - ENDOCRINE CONFERENCE 2025 (Spain)
- Diabetic Complications: Neuropathy, Nephropathy - Diabetes-2026 (UK)
- Diabetic Complications: Prevention and Management - Euro Diabetes 2025 (Italy)
- Diabetic nephritis - ENDOCRINE CONFERENCE 2025 (Spain)
- Diabetic Nephropathy - Herbal Diabetes 2025 (France)
- Diabetic Nephropathy - Diabetes Meeting 2026 (Canada)
- Diabetic Nutrition and Diet - Herbal Diabetes 2025 (France)
- Diabetic Nutrition and Diet - Euro Endocrinology 2026 (UK)
- Diabetic Retinopathy - Euro Diabetes 2025 (Italy)
- Diabetic Retinopathy - Herbal Diabetes 2025 (France)
- Diabetic Retinopathy - Diabetes Conference 2026 (Netherlands)
- Diabetic Retinopathy Detection Advances - Diabetes AsiaPacific 2025 (Germany)
- Dialysis and Transplantation - Euro Diabetes 2025 (Italy)
- Dialysis and Transplantation - Diabetes Conference 2026 (Netherlands)
- Dietary Patterns on Diabetes Control - Diabetes Meeting 2026 (Canada)
- Digital Diabetes Health - Diabetic Nutrition 2025 (Italy)
- Digital Diabetes Health - Diabetic Nutrition 2025 (Italy)
- Digital Health - Euro Endocrinology 2026 (UK)
- Digital Therapeutics for Diabetes - Diabetes AsiaPacific 2025 (Germany)
- Disorders of Bone and Mineral Metabolism - Global Diabetes 2026 (France)
- EDCs (Endocrine Disrupting Chemicals) - ENDOCRINE CONFERENCE 2025 (Spain)
- Emerging Therapies in Thyroid Disorders - Endocrinology Conference 2025 (France)
- Emerging Treatments and Technologies - Herbal Diabetes 2025 (France)
- Endocrine and Disorders - Herbal Diabetes 2025 (France)
- Endocrine Cancer - Euro Endocrinology 2026 (UK)
- Endocrine Care in Gender-Affirming Therapy - Global Diabetes 2026 (France)
- Endocrine Complications of Diabetes - ENDOCRINOLOGY-2025 (Canada)
- Endocrine Disease and Cancer - Endocrinology Conference 2025 (France)
- Endocrine Disorders - Euro Endocrinology 2026 (UK)
- Endocrine Disorders in Children and Adolescents - Global Diabetes 2026 (France)
- Endocrine Disruptions and Environmental Factors - ENDOCRINOLOGY-2025 (Canada)
- Endocrine Disruptions and Environmental Factors - Diabetes Conference 2026 (Netherlands)
- Endocrine Disruptors and Environmental Health - Endocrinology Conference 2025 (France)
- Endocrine Glands and Hormones - ENDOCRINE CONFERENCE 2025 (Spain)
- Endocrine Health in Women - Global Diabetes 2026 (France)
- Endocrine Pathophysiology - Endocrinology Conference 2025 (France)
- Endocrine Perspectives on Obesity - Global Diabetes 2026 (France)
- Endocrine Surgery: Challenges and Innovations - Endocrinology Conference 2025 (France)
- Endocrinology - Euro Endocrinology 2026 (UK)
- Endocrinology and Aging - ENDOCRINOLOGY-2025 (Canada)
- Endocrinology and Aging - Diabetes Conference 2026 (Netherlands)
- Endocrinology and Diabetes - ENDOCRINE CONFERENCE 2025 (Spain)
- Endocrinology and Diabetes - Diabetes Conference 2026 (Netherlands)
- Endocrinology in Special Populations - Endocrinology Conference 2025 (France)
- Endocrinology: Disorders and Treatment - Diabetes Meeting 2026 (Canada)
- Epidemiology and mechanisms - Euro Diabetes 2025 (Italy)
- Gender-Specific Approaches in Endocrinology - Endocrinology Conference 2025 (France)
- Genetic Diabetes - Diabetes Meeting 2026 (Canada)
- Genomic Advances in Endocrine Disorders - Global Diabetes 2026 (France)
- Genomics and Molecular Endocrinology - ENDOCRINOLOGY-2025 (Canada)
- Genomics and Molecular Endocrinology - Diabetes Conference 2026 (Netherlands)
- Gestational Diabetes - Euro Endocrinology 2026 (UK)
- Gestational Diabetes & Women’s Health - Diabetes-2026 (UK)
- Gestational Diabetes and Reproductive Endocrinology - ENDOCRINOLOGY-2025 (Canada)
- Gestational Diabetes: Maternal and Fetal Health - Euro Diabetes 2025 (Italy)
- Gestational Diabetes: Maternal and Fetal Health - Diabetes Conference 2026 (Netherlands)
- Global Diabetes Awareness and Education - Endocrinology Conference 2025 (France)
- Global Epidemiology and Public Health Challenges in Diabetes - Diabetes-2026 (UK)
- Global Health Strategies for Diabetes and Endocrine Care - Endocrinology Conference 2025 (France)
- Global Trends in Endocrine and Diabetes Care - ENDOCRINOLOGY-2025 (Canada)
- Gut Microbiome and Diabetes - Diabetes AsiaPacific 2025 (Germany)
- Gut Microbiome and Diabetes - Diabetes Meeting 2026 (Canada)
- Gynecology - ENDOCRINE CONFERENCE 2025 (Spain)
- Healthcare Policy, Economics & Access to Diabetes Care - Diabetes-2026 (UK)
- Herbal, Alternative & Integrative Therapies in Diabetes - Diabetes-2026 (UK)
- Hormonal Changes in Aging Populations - Global Diabetes 2026 (France)
- Hormonal Imbalances and Metabolic Disorders - Endocrinology Conference 2025 (France)
- Hormonal Impact of Chronic Disease - Global Diabetes 2026 (France)
- Hormonal Replacement Therapy - Euro Endocrinology 2026 (UK)
- Hormonal Therapies for Menopause and Aging - Endocrinology Conference 2025 (France)
- Hormones and Sleep Regulation - Global Diabetes 2026 (France)
- Hormones in Cancer Development and Therapy - Global Diabetes 2026 (France)
- Human Weight Regulation and Obesity - Diabetic Nutrition 2025 (Italy)
- Hyperglycaemia - ENDOCRINE CONFERENCE 2025 (Spain)
- Immune Therapies for Type 1 Diabetes - Diabetes AsiaPacific 2025 (Germany)
- Immunotherapy and Autoimmunity in Type 1 Diabetes - Diabetes-2026 (UK)
- Infectious Diseases and Endocrine Dysfunction - Global Diabetes 2026 (France)
- Inflammation and Insulin Resistance - Diabetes AsiaPacific 2025 (Germany)
- Innovations in Diabetes Education - Diabetes Meeting 2026 (Canada)
- Innovations in Diabetes Prevention - Endocrinology Conference 2025 (France)
- Innovative Technologies for Diabetes Management - ENDOCRINE CONFERENCE 2025 (Spain)
- Innovative Technologies in Endocrinology and Diabetes - ENDOCRINOLOGY-2025 (Canada)
- Innovative Technologies in Endocrinology and Diabetes - Diabetes Conference 2026 (Netherlands)
- Innovative Therapies and Drug Development - Endocrinology Conference 2025 (France)
- Insulin Resistance - Euro Endocrinology 2026 (UK)
- Insulin Resistance & Insulin therapy - Herbal Diabetes 2025 (France)
- Insulin Therapy & Delivery Technologies - Diabetes-2026 (UK)
- Integrative and Holistic Approaches - ENDOCRINOLOGY-2025 (Canada)
- Integrative and Holistic Approaches - Diabetes Conference 2026 (Netherlands)
- Lifestyle Interventions: Diet, Exercise & Behavioral Therapy - Diabetes-2026 (UK)
- Managing Rare Endocrine Diseases - Global Diabetes 2026 (France)
- Menstrual Irregularities - Euro Endocrinology 2026 (UK)
- Mental Health and Diabetes - Herbal Diabetes 2025 (France)
- Mental Health in Diabetes Care - Endocrinology Conference 2025 (France)
- Metabolic Reprogramming in Diabetes - Diabetes AsiaPacific 2025 (Germany)
- Metabolic Surgery and Endocrine Outcomes - Endocrinology Conference 2025 (France)
- Microvascular Complications of Diabetes - Diabetic Nutrition 2025 (Italy)
- Mobile Health Applications - Euro Diabetes 2025 (Italy)
- Mobile Health Applications - Diabetes Conference 2026 (Netherlands)
- Multiple Endocrine Neoplasia - ENDOCRINE CONFERENCE 2025 (Spain)
- Nanotechnology in Diabetes Treatment - Herbal Diabetes 2025 (France)
- Nanotechnology in Diabetes Treatment - Diabetes AsiaPacific 2025 (Germany)
- Natural remedies for diabetes - ENDOCRINE CONFERENCE 2025 (Spain)
- Neuroendocrine Response to Trauma and Stress - Global Diabetes 2026 (France)
- Neuroendocrinology - Euro Endocrinology 2026 (UK)
- Neuroendocrinology and the Brain-Hormone Connection - Endocrinology Conference 2025 (France)
- New Insulins & Insulin Pumps - Diabetic Nutrition 2025 (Italy)
- Non-Insulin Based Diabetes Therapies - Diabetic Nutrition 2025 (Italy)
- Novel Therapeutic Frontiers in Endocrinology - Global Diabetes 2026 (France)
- Nutrition and Diet - Diabetic Nutrition 2025 (Italy)
- Nutrition and Endocrine Wellness - Global Diabetes 2026 (France)
- Nutrition and Lifestyle Interventions in Diabetes - Euro Diabetes 2025 (Italy)
- Nutrition and Lifestyle Interventions in Diabetes - Diabetes Conference 2026 (Netherlands)
- Obesity - Euro Endocrinology 2026 (UK)
- Obesity and Insulin Resistance - Endocrinology Conference 2025 (France)
- Obesity and Metabolic Syndrome - ENDOCRINE CONFERENCE 2025 (Spain)
- Obesity and Metabolic Syndrome - ENDOCRINOLOGY-2025 (Canada)
- Obesity and Metabolism for Diabetes - Herbal Diabetes 2025 (France)
- Obesity and Metabolism for Diabetes - Diabetes Meeting 2026 (Canada)
- Obesity and Weight Management - Endocrinology Conference 2025 (France)
- Obesity, Metabolic Syndrome & Insulin Resistance - Diabetes-2026 (UK)
- Pathological Insights in Endocrinology - Global Diabetes 2026 (France)
- Pediatric and Adolescent Diabetes - Diabetes-2026 (UK)
- Pediatric Endocrinology - ENDOCRINE CONFERENCE 2025 (Spain)
- Pediatric Endocrinology - Euro Endocrinology 2026 (UK)
- Pediatric Endocrinology and Diabetes - ENDOCRINOLOGY-2025 (Canada)
- Pediatric Endocrinology and Diabetes - Diabetes Conference 2026 (Netherlands)
- Pediatric Endocrinology: Advances and Challenges - Endocrinology Conference 2025 (France)
- Peripheral Hormone Action in Health and Disease - Diabetic Nutrition 2025 (Italy)
- Personalized and Precision Medicine in Endocrinology - Endocrinology Conference 2025 (France)
- Personalized Diabetes Management - Diabetes AsiaPacific 2025 (Germany)
- Pharmacogenomics in Diabetes - Diabetes AsiaPacific 2025 (Germany)
- Physical Activity Guidelines - Euro Diabetes 2025 (Italy)
- Precision Medicine & Pharmacogenomics in Diabetes - Diabetes-2026 (UK)
- Prediabetes to Late-Stage Complicated Diabetes - Herbal Diabetes 2025 (France)
- Prophylaxis and Applications - ENDOCRINE CONFERENCE 2025 (Spain)
- Psychosocial Aspects of Diabetes Care - Euro Diabetes 2025 (Italy)
- Psychosocial Aspects of Diabetes Care - Diabetes Conference 2026 (Netherlands)
- Puberty and its Disorders - ENDOCRINE CONFERENCE 2025 (Spain)
- Rare Endocrine Disorders - ENDOCRINOLOGY-2025 (Canada)
- Risk Factors and Related Diseases of Diabetes - Diabetes Meeting 2026 (Canada)
- Risks and Benefits of New Therapies - Herbal Diabetes 2025 (France)
- Senescence and Obesity/Diabetes - Diabetic Nutrition 2025 (Italy)
- SGLT2 Inhibitors in Diabetes: - Diabetes AsiaPacific 2025 (Germany)
- Skeletal Health & Osteopenia - ENDOCRINE CONFERENCE 2025 (Spain)
- Smart Insulin Delivery Systems - Diabetes AsiaPacific 2025 (Germany)
- Stem Cell Therapy for Diabetes: - Diabetes AsiaPacific 2025 (Germany)
- Surgical Endocrinology - ENDOCRINE CONFERENCE 2025 (Spain)
- Technological Advances in Diabetes and Endocrinology - Endocrinology Conference 2025 (France)
- The Role of Gut Microbiota in Endocrinology - Endocrinology Conference 2025 (France)
- Thyroid Disorders - Euro Endocrinology 2026 (UK)
- Thyroid Disorders - Diabetes Meeting 2026 (Canada)
- Thyroid Disorders: Diagnosis and Management - ENDOCRINOLOGY-2025 (Canada)
- Thyroid Disorders: Diagnosis and Management - Diabetes Conference 2026 (Netherlands)
- Translational Endocrinology and Diabetes Research - ENDOCRINOLOGY-2025 (Canada)
- Transplantation and Artificial Pancreas - Herbal Diabetes 2025 (France)
- Type 1 Diabetes - Euro Endocrinology 2026 (UK)
- Type 1 Diabetes - Diabetes Meeting 2026 (Canada)
- Type 1 Diabetes Mellitus: Advances in Understanding and Treatment - Euro Diabetes 2025 (Italy)
- Type 2 Diabetes - Euro Endocrinology 2026 (UK)
- Type 2 Diabetes - Diabetes Meeting 2026 (Canada)
- Type 2 Diabetes: From Pathophysiology to Personalized Management - Euro Diabetes 2025 (Italy)
- Types of Diabetes - Herbal Diabetes 2025 (France)
- Women’ Health and Diabetes - ENDOCRINE CONFERENCE 2025 (Spain)