Type 1 Diabetes

Type 1 also known as juvenile diabetes and occurs when the body fails to produce insulin. People with Type 1 diabetes are insulin-dependent, which means they must take artificial insulin daily to stay alive otherwise some other rare forms of diabetes would be directly inherited. That includes Maturity Onset Diabetes in the Young (MODY), and diabetes due to mutations in mitochondrial DNA. In addition to the consequences of abnormal metabolism of glucose it can cause hyperlipidaemia, glycosylation of proteins. Type1 Diabetes is caused by the autoimmune destruction of the beta cells of the pancreas and represents approximately 10.5% of all cases with diabetes. Generally lifelong insulin therapy is the only treatment for this disorder. Without exogenous insulin injections, individuals with Type1 Diabetes will not survive.                      

 

  • Genetic studies on Type1 and Type 2 Diabetes
  • The value of monogenic subtypes of diabetes
  • Factors contributing to the complexity of analysis
  • DNA diagnostics and pharmacogenetics in clinical trials

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